This book contributes to emerging debates about Levelling Up the UK Economy, considering these alongside the nature of, and trends in, both the political economy and spatial disparities. Drawing on a complex systems framing, the book pulls together a range of evidence to provide insights about the agenda from macro, meso and micro levels of analyses, including utilising qualitative data from a small scoping study with Directors of Regeneration across several 'left behind' places and 25 residents of 'left behind' Redcar & Cleveland in Teesside. The book outlines phases in capitalism's development, particularly the shift from post-war capitalism to a post-industrial and neoliberal society and the implications for spatial inequalities. The 2022 Levelling Up White Paper is analysed alongside a focus on the role of local government relative to the agenda. The book offers an empirical case study of 'left behind' Redcar & Cleveland, exposing deindustrialisation, insecure employment, crime, anti-social behaviour and sentiments on a North South divide and Levelling Up. We suggest that only a transformative change in the political economy, including significant and sustained investment at different spatial levels, is likely to achieve the ambition to Level Up.