Left Hand of the Moon is an American Romeo and Juliet story about doomed love between the very young. In the early 1800s, as the fledgling United States completes the Louisiana Purchase and marches troops through the newly acquired state, executing by firing squad the freed adult children of enslaved women and their owners, an enslaved teen and her owner's youngest son run away to live together. They have grown up together and have always trusted and loved each other. Now that adulthood threatens to force them into roles they would rather die than play, the passionate young couple determines to create their own future.

Defying French and Spanish colonial custom and the new American laws, Aurélie and Jules masquerade as revelers and escape into the festive chaos of All Hallows' Eve in old New Orleans. On this night when spirits walk abroad, the lovers discover they have begun an adventure that may ultimately shatter every illusion they have about themselves, their families, their countrymen, and each other. Perhaps some dreams are best left undisturbed.