Neill KJ Adhikari, Staff physician, Associate Scientist, Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada Naeem Ali Derek C Angus, Distinguished Professor and Mitchell P. Fink Endowed Chair in Critical Care Medicine, Professor of Critical Care Medicine, Medicine, Health Policy and Management, and Clinical and Translational Science, The CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, USA Sean M Bagshaw, Associate Professor, Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada Matthew Baldwin, Assistant Professor of Clinical Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, USA Amelia Barry, Department of M